产品货号：
Z32613
中文名称：
APC抗体
英文名称：
Anti-APC Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-APC Antibody |
| 指标别名 | adenomatous polyposis coli;APC;BTPS2;Deleted in polyposis 2.5;DP2;DP2.5;DP3;GS;Protein APC |
| 克隆性 | Monoclonal |
| 检验物种 | human,rat |
| 应用范围 | WB,IHC,ICC/IF,IP |
| 基因名称 | APC |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human APC Tumor suppressor.Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator.APC activity is correlated with its phosphorylation state.Activates the GEF activity of SPATA13 and ARHGEF4.Plays a role in hepatocyte growth factor (HGF) -induced cell migration.Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells.Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. |
| 实际分子量 | 160KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway.It is also involved in other processes including cell migration and adhesion,transcriptional activation,and apoptosis.Defects in this gene cause familial adenomatous polyposis (FAP),an autosomal dominant pre-malignant disease that usually progresses to malignancy.Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.[provided by RefSeq,Jul 2008] |
| Uniprot ID | P25054 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 |
相关搜索：APC抗体，APC单抗，Anti-APC Antibody